Clinical Trials
Search our team at AdventHealth Research Institute
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NCT04471909
TRIOMPHE - A Multi-arm, Multi-Center, Non-Randomized, Prospective, Clinical Study to Evaluate the Safety and Effectiveness of the NEXUS Aortic Arch Stent Graft System in Treating Thoracic Aortic Lesions Involving the Aortic Arch
This study is not currently enrolling.Research Area: Transplant ResearchResearch Location: Orlando, FloridaThis study involves research. The purpose of this research study is to continue to test how well the Endospan NEXUS Aortic Arch Stent Graft System performs in the treatment of a diseased aortic arch...
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NCT03683186
ADVANCE OUTCOMES - A Study Evaluating the Efficacy and Safety of Ralinepag To Improve Treatment Outcomes in PAH Patients
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaA research study is a scientific way to improve or develop new methods of health care. Studies are designed to answer specific questions on how to prevent, diagnose, or treat diseases and disorders...
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Randomized Trial on Hybrid vs Non-Hybrid ESD for Colorectal Polyps
This study is not currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaWe invite you to take part in a research study because you have colorectal polyp and are being treated here at AdventHealth Orlando. A clinical trial (research study) is done when researchers...
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NCT04537377
A Phase I/II, Multicenter, Non-randomized, Open Label, Adaptive Design, 5-year Follow up, Single Dose-escalation Study of VTX-801 in Adult Patients with Wilson’s Disease.
This study is not currently enrolling.Associated Conditions: Wilsons DiseaseResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThis Clinical Trial is being conducted to assess the effects of an experimental drug (study drug) called VTX-801 intended to treat Wilson’s Disease (WD). The purpose of this clinical study is to...
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NCT05064878
A Phase 3, Randomized, Double-blind, Placebo-Controlled, Fixed-Dose, Multicenter Study to Examine the Efficacy and Safety of ZX008 in Subjects with CDKL5 deficiency disorder followed by an Open-Label Extension.
This study is not currently enrolling.Associated Conditions: EpilepsyResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this informed consent form is to collect data about the non-paid caregiver of a subject that is participating in ZX008-2103 study. You, as the non-paid caregiver, are being asked to...
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NCT04945460
A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) due to Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is not currently enrolling.Associated Conditions: Pulmonary HypertensionResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYou are being asked to take part in a research study of an experimental treatment called
sotatercept. “Experimental” means that sotatercept is currently being tested and is not
approved for sale by... -
NCT05206773
A Randomized, Double-blind, Placebo-controlled, 12-month Phase 3 Study to Evaluate the Effect of Venglustat on Neuropathic and Abdominal Pain in Male and Female Adults with Fabry Disease who are Treatment-naïve or Untreated for At least 6 Months
This study is not currently enrolling.Research Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of the study is to evaluate daily oral doses of the study drug called venglustat compared to placebo: what is the effectiveness (how well it works) on symptoms of the Fabry disease, mainly...
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Conservative Fluid Management in the First Week of Life Reduces the Risk of Prolonged Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaTo retrospectively collect and analyze the data to show that a change in practice at the AdventHealth Orlando Neonatal Intensive Care Unit (NICU), implementing conservative fluid intake during the...
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NCT03321734
INTERMITTENT HYPOXIA AND CAFFEINE IN INFANTS BORN PRETERM
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaYou are being asked to allow your baby to be in this research study because your premature baby was given the medication caffeine as treatment for his/her immature breathing in the neonatal intensive...
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NCT04935359
A randomized, three-arm, double-blind, placebo-controlled, phase III study, comparing NIS793 with or without spartalizumab in combination with gemcitabine and nab-paclitaxel versus matching placebos combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)
This study is not currently enrolling.Associated Conditions: Pancreatic CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line mPDAC. This study...
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NCT04628481
GLADIATOR: A phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes and a low residual β-cell function at baseline.
This study is not currently enrolling.Associated Conditions: Diabetes-Drug StudyResearch Area: Translational ResearchResearch Location: Orlando, FloridaThe purpose of this study is to check and collect data of how the body absorbs, distributes and gets rid of the study drug in the blood during the first cycle of LDX0319 study treatment. These data...
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NCT04811092
HYPERION A Phase 3, Randomized, Doubleblind, Placebo-controlled Study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate-and High-risk PAH Patients
This study is not currently enrolling.Associated Conditions: Pulmonary HypertensionResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaPulmonary arterial hypertension (PAH) is a disease affecting the blood vessels of the lungs. PAH leads to increased pressure in the blood vessels of the lungs which further leads to straining of the...