All Clinical Trials
Search our team at AdventHealth Research Institute
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MODIFY: A Case-Control, Observational, Proof of Mechanism Study to Define Microbiome-Mediated Gut Dysfunction Across the Spectrum of Non-Alcoholic Fatty Liver Disease.
This study is not currently enrolling.Associated Conditions: Liver-NAFL, NASHResearch Area: Translational ResearchThis study is being done to understand if the bacteria that are in your colon (the gut microbiome) get into the cells of the intestinal wall in people with fatty liver or fibrosis compared to people...
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NCT05046730
SEAM Trial: Sutureless End to End Anastomosis by Magnetic Compression: A Study to Evaluate Safety and Effectiveness of the GI Window’s Self-Forming Magnet (SFM) Anastomosis Device: A Historically Controlled Propensity Matched Study
This study is not currently enrolling.Research Area: Digestive Health and SurgeryYou are being asked to participate in this research study because you will be undergoing an ileostomy reversal surgery (also referred to as “ileostomy closure”). A reversal of ileostomy is an...
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NCT04140526
Safety, Pharmacokinetics (PK), and Efficacy of ONC-392 as a Single Agent and in Combination with Pembrolizumab in Advanced Solid Tumors and NSCLC: An Open-label Phase IA/IB Study.
This study is not currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Celebration, FloridaThis is a research study to find out if an experimental drug called ONC-392 is safe and effective in cancer patients and how the drug is absorbed and processed in the body of patients with cancer. ONC...
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NCT04945460
A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) due to Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is not currently enrolling.Associated Conditions: Pulmonary HypertensionResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaYou are being asked to take part in a research study of an experimental treatment called
sotatercept. “Experimental” means that sotatercept is currently being tested and is not
approved for sale by... -
NCT05206773
A Randomized, Double-blind, Placebo-controlled, 12-month Phase 3 Study to Evaluate the Effect of Venglustat on Neuropathic and Abdominal Pain in Male and Female Adults with Fabry Disease who are Treatment-naïve or Untreated for At least 6 Months
This study is not currently enrolling.Research Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of the study is to evaluate daily oral doses of the study drug called venglustat compared to placebo: what is the effectiveness (how well it works) on symptoms of the Fabry disease, mainly...
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NCT05258942
MyLeukoMAP Genomic Survival Prediction Assay
This study is not currently enrolling.Associated Conditions: Heart FailureResearch Area: Transplant ResearchHeart failure (HF) can cause other organs to shut down. This process appears to involve the white blood cells of the immune system. Our data show that abnormal gene activation or suppression of white...
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NCT05027971
Multi-center, open label, prospective study to document on-going post market safety and performance of Flexiva Pulse High Power Single-Use Laser Fibers.
This study is not currently enrolling.Research Area: Digestive Health and SurgeryMulti-center, open label, prospective study to document on-going post market safety and performance of Flexiva Pulse High Power Single-Use Laser Fibers.
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Conservative Fluid Management in the First Week of Life Reduces the Risk of Prolonged Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaTo retrospectively collect and analyze the data to show that a change in practice at the AdventHealth Orlando Neonatal Intensive Care Unit (NICU), implementing conservative fluid intake during the...
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NCT03321734
INTERMITTENT HYPOXIA AND CAFFEINE IN INFANTS BORN PRETERM
This study is not currently enrolling.Associated Conditions: NeonatalResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaYou are being asked to allow your baby to be in this research study because your premature baby was given the medication caffeine as treatment for his/her immature breathing in the neonatal intensive...
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Optune Lua for the treatment of adult patients with unresectable, locally advanced or metastatic, malignant pleural mesothelioma (MPM) to be used concurrently with pemetrexed and platinum-based chemotherapy
This study is not currently enrolling.Associated Conditions: Malignant Pleural MesotheliomaResearch Area: Clinical Cancer ResearchOptune Lua is indicated for the treatment of adult patients with unresectable, locally advanced or metastatic, malignant pleural mesothelioma (“MPM”) to be used concurrently with pemetrexed and...
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NCT05076838
An Open-Label, Single-Dose, Pharmacokinetics Study of VALTOCO with Open-Label Safety Period in Pediatric Subjects with Epilepsy
This study is not currently enrolling.Associated Conditions: EpilepsyResearch Area: Neuroscience ResearchThis is a research study to evaluate the pharmacokinetics (PK), safety and tolerability after a single intranasal dose of VALTOCO (diazepam nasal spray), followed by a long-term safety period, where...
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NCT05107856
A Phase 1, Open-Label, Multicenter, Dose Escalation Study of PRT1419 Injection in Patients with Relapsed/Refractory Hematologic Malignancies
This study is not currently enrolling.Associated Conditions: LeukemiaResearch Area: Clinical Cancer ResearchThe purpose of this research study is to test the safety of PRT1419 at different dose levels to find out what effects, good and/or bad, PRT1419 has on you and your type of cancer. The information...