Clinical Trials
Search our team at AdventHealth Research Institute
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NCT05685004
Randomized controlled Phase 2b clinical trial to evaluate the safety and efficacy of TVI-Brain-1 combined with conformal radiotherapy and temozolomide compared to standard therapy as a treatment for newly diagnosed O6-methylguanine methyltransferase negative (MGMT unmethylated) grade 4 astrocytoma (glioblastoma multiforme; glioblastoma; GBM).
This study is not currently enrolling.Associated Conditions: Brain CancerResearch Area: Clinical Cancer ResearchThis clinical trial is being performed because there is a need for safer and more effective treatments for glioblastomas. The purpose of this specific clinical study is to determine how safe and...
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NCT05757869
A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, Versus Apixaban in Participants with Atrial Fibrillation
This study is not currently enrolling.Research Area: Heart, Lung and Vascular ResearchResearch Location: Tampa, FloridaThe purpose of this research study is to compare the effects of an experimental drug, milvexian, to the comparator drug, apixaban, to determine if it is safe and useful in reducing the risk of stroke...
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NCT04083599
GCT1042-01: A First-in-Human, Open-label, Dose-escalation Trial with Expansion Cohorts to Evaluate Safety and Anti-tumor Activity of GEN1042 in Subjects with Malignant Solid Tumors
This study is not currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaGEN1042 is a bispecific antibody that crosslinks CD40 on antigen-presenting cells with 4-1BB on activated T cells, thereby inducing conditional stimulation of and co-stimulatory activity on both cell...
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NCT05639751
PRT3789-01: A Phase 1 Open-Label, Multi-Center, Safety and Efficacy Study of PRT3789 in Participants with Select Advanced or Metastatic Solid Tumors with a SMARCA4 Mutation
This study is not currently enrolling.Associated Conditions: Multiple Tumor TypesResearch Area: Clinical Cancer ResearchResearch Location: Celebration, FloridaThe purpose of this research study is to test the safety of PRT3789 at different dose levels to find out what effects, good and/or bad, PRT3789 has on you and your type of cancer. The information...
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NCT05198674
The SPYRAL AFFIRM Global Clinical Study of Renal Denervation with the Symplicity Spyral Renal Denervation System in Subjects with Uncontrolled Hypertension (SPYRAL AFFIRM)
This study is not currently enrolling.Associated Conditions: Interventional CardiologyResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaThe purpose of this study is to study renal denervation with the Symplicity Spyral Renal Denervation system in patients with varying severity of uncontrolled high blood pressure and associated...
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NCT05840211
A Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Patients with Hormone Receptor-Positive (HR+)/Human Epidermal Growth Factor Receptor 2-Negative (HER2−) (HER2 IHC0 or HER2-low [IHC 1+, IHC 2+/ISH−]) Inoperable, Locally Advanced, or Metastatic Breast Cancer and Have Received Endocrine Therapy ASCENT 07
This study is not currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Altamonte, FloridaThe purpose of this study is to see if sacituzumab govitecan can improve life spans of patients with HR+/HER2- metastatic breast cancer and their tumor does not grow or spread when compared to current...
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NCT05629585
D926XC00001: Phase 3, Open-Label, Randomized Study of Datopotamab Deruxtecan with or without Durvalumab Versus Investigator’s Choice of Therapy in Patients with Stage I-III Triple Negative Breast Cancer who have Residual Invasive Disease in Breast and/or Axillary Lymph Nodes Following Neoadjuvant Systemic Therapy and Surgical Resection (TROPION-Breast03)
This study is not currently enrolling.Associated Conditions: Breast CancerResearch Area: Clinical Cancer ResearchResearch Location: Altamonte, FloridaWe are doing this study to learn more about whether an investigational drug called datopotamab deruxtecan (also called Dato-DXd), either alone or in combination with another investigational drug...
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NCT05457556
A Multi-Center, Phase 3, Randomized Trial of Matched Unrelated Donor (MUD) versus HLA-Haploidentical Related (Haplo) Myeloablative Hematopoietic Cell Transplantation for Children, Adolescents, and Young Adults (AYA) with Acute Leukemia or Myelodysplastic Syndrome (MDS)
This study is not currently enrolling.Associated Conditions: Cancer, Multiple Tumor TypesResearch Area: Pediatric Research and Clinical TrialsResearch Location: Orlando, FloridaYou are being asked to take part in this research study because you have been diagnosed with acute leukemia or myelodysplastic syndrome (MDS).
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NCT04419779
REVITALIZE-1: A Prospective randomized, double-blind, sham-controlled, multi-center pivotal study to evaluate the efficacy and safety of Duodenal Mucosal Resurfacing (DMR) using the Revita system in subjects with type 2 diabetes on insulin therapy.
This study is not currently enrolling.Research Area: Translational ResearchResearch Location: Orlando, FloridaStudy Purpose: The purpose of this study is to demonstrate the efficacy and safety of the Fractyl DMR Procedure using the Revita System compared to a sham.
To be enrolled in this study, you must meet...
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NCT05766813
A Randomized, Double-blind, Placebo-controlled Multicenter Study to Assess the Efficacy and Safety of Lenrispodun as Adjunctive Therapy in the Treatment of Patients with Motor Fluctuations due to Parkinson’s Disease”
This study is not currently enrolling.Associated Conditions: ParkinsonsResearch Area: Neuroscience ResearchResearch Location: Orlando, FloridaThe purpose of this clinical research study is to look at an investigational study drug called lenrispodun. The study will investigate if lenrispodun can help to increase the time of good control of...
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NCT05945433
Anova Surgical System – Registry Study
This study is not currently enrolling.Research Area: Pediatric Research and Clinical TrialsYou are invited to take part in a patient registry research study. A patient registry is an organized way to collect observational data from a large group of patients undergoing the same procedure...
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NCT05754333
ASP5354: A Phase 3, Multicenter, Prospective, Randomized, Open-label Study for Intraoperative Ureter(s) Visualization When Using ASP5354 with Near-infrared Fluorescence (NIR-F) Imaging in Participants Undergoing Minimally Invasive and Open Abdominopelvic Surgeries.
This study is not currently enrolling.Research Area: Digestive Health and SurgeryResearch Location: Orlando, FloridaStudy Purpose: The biological father of your child is/was participating in a research study of an Investigational or experimental medicine that has not received approval from governmental regulatory...