Clinical Trials
Search our team at AdventHealth Research Institute
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NCT04669899
Phase 1 First-in-Human Study of Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) Inhibitor Monoclonal Antibody (mAb) JTX8064, as Monotherapy and in Combination with a Programmed Cell Death Receptor-1 (PD-1) Inhibitor, in Adult Subjects with Advanced Refractory Solid Tumor Malignancies
This study is not currently enrolling.Associated Conditions: Multiple MyelomaResearch Area: Clinical Cancer ResearchA medical research study for participants who have been diagnosed with a solid tumor (i.e. cancer) and currently, the tumor is unresponsive to approved treatments, approved treatments are worsening...
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NCT04998747
A Phase 1b Open-label Study Evaluating the Safety and Pharmacokinetics of Subcutaneous AMG 701 for the Treatment of Relapsed or Refractory Multiple Myeloma (ProxiMMity-1)
This study is not currently enrolling.Associated Conditions: Multiple MyelomaResearch Area: Clinical Cancer ResearchParticipants who have have relapsed (returning) and refractory (stopped responding to treatment) multiple myeloma (RRMM) will be invited to take part in this study. This study is being done to learn...
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NCT04935359
A randomized, three-arm, double-blind, placebo-controlled, phase III study, comparing NIS793 with or without spartalizumab in combination with gemcitabine and nab-paclitaxel versus matching placebos combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)
This study is not currently enrolling.Associated Conditions: Pancreatic CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line mPDAC. This study...
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NCT04628481
GLADIATOR: A phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes and a low residual β-cell function at baseline.
This study is not currently enrolling.Associated Conditions: Diabetes-Drug StudyResearch Area: Translational ResearchResearch Location: Orlando, FloridaThe purpose of this study is to check and collect data of how the body absorbs, distributes and gets rid of the study drug in the blood during the first cycle of LDX0319 study treatment. These data...
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Phase II Trial of Trilaciclib added to Chemotherapy plus Pembrolizumab in the First-line Treatment of patients with Advanced Non-Small Cell Lung Cancer.
This study is not currently enrolling.Associated Conditions: Lung CancerResearch Area: Clinical Cancer Research -
NCT04403022
A Prospective, Multi-Center Investigation of the da Vinci SP Surgical System in Colorectal Procedures for Benign and Malignant Disease.
This study is not currently enrolling.Research Area: Digestive Health and SurgeryThe purpose of this study is to collect data to evaluate safety and performance of the da Vinci SP Surgical System, Instruments and Accessories in colorectal procedures. These colorectal procedures...
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NCT04742907
Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial to Evaluate the Safety and Efficacy of TU-100 as an Adjunct to an Enhanced Recovery after Surgery (ERAS) Protocol in Subjects Undergoing Bowel Resection.
This study is not currently enrolling.Research Area: Digestive Health and SurgeryThis multicenter, randomized, double-blinded, placebo-controlled study will evaluate the effect of TU-100 on resolution of POI in subjects undergoing open or laparoscopic BR. Straight, hand-assisted...
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NCT05046158
Randomized Clinical Trial to Compare Transforming Powder and Standard of Care Dressing Therapies to Heal Diabetic Foot Ulcers”
This study is not currently enrolling.Research Area: Orthopedic ResearchYou are invited to take part in this research study because you have diabetes, are between the ages of eighteen (18) and eighty-nine (89) years old and have a diabetic foot ulcer (wound) for thirty...
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NCT04440189
Use of GID SVF-2 Device to Produce Autologous Adipose-Derived Stromal Vascular Fraction for Treatment of Osteoarthritis of the Knee: A Pivotal Medical Device Randomized Concurrent Controlled Study
This study is not currently enrolling.Associated Conditions: OsteoarthritisResearch Area: Orthopedic ResearchA research study that intends to determine if an injection of stromal vascular fraction (SVF) cells derived from your own fat (adipose) will relieve pain and increase function in one of your...
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NCT04811092
HYPERION A Phase 3, Randomized, Doubleblind, Placebo-controlled Study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate-and High-risk PAH Patients
This study is not currently enrolling.Associated Conditions: Pulmonary HypertensionResearch Area: Heart, Lung and Vascular ResearchResearch Location: Orlando, FloridaPulmonary arterial hypertension (PAH) is a disease affecting the blood vessels of the lungs. PAH leads to increased pressure in the blood vessels of the lungs which further leads to straining of the...
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NCT04089358
StepByStep: A Randomized Trial of a Mobile Health and Social Media Physical Activity Intervention among Adolescent and Young Adult Childhood Cancer Survivors
This study is not currently enrolling.Associated Conditions: Pediatric CancerResearch Area: Clinical Cancer ResearchResearch Location: Orlando, FloridaThe overall goals of this study are: (1) To compare the effect of 2 different physical activity programs on physical activity levels in adolescents and young adults who received and completed...
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NAD-flux: Measurement of NAD+ Synthesis in Human Skeletal Muscle
This study is not currently enrolling.Associated Conditions: WellnessResearch Area: Translational ResearchResearch Location: Orlando, FloridaNicotinamide adenine dinucleotide (NAD) is a vitally important substance that is found in all cells of the body. Elevated levels of NAD are linked to health and well-being. The key objective of this...